The cement-extracted liquid induced no acute toxicity in mice, pyrogenic reaction in rabbits, genetic toxicity in mice or allergic reaction in guinea pigs. 材料原液未引起小鼠急性毒性反应、新西兰白兔热原反应、小鼠遗传毒性及豚鼠过敏反应。
However, LPS also shows strong toxic reaction ( Shwartzman reaction, pyrogenic reaction, etc) that hinders its clinical application. Many researchers have been committed to the toxicity attenuation of LPS. 但是LPS同时表现出强烈的毒性反应(Shwartzman反应,热原性等),因此阻碍了它在临床上的应用,所以许多研究者一直致力于LPS的减毒研究。